In melanoma, the performance of Mutation_load, IFN-gamma, Nonsyn_mutation_load, PD-L1 and Expanded immune signature were superior to the other biomarkers (Figure 5A, Figures S21 and S22, mean AUC = 0.68, 0.67, 0.66, 0.65, 0.65, respectively). This evidence concerns the gene CD274 and melanoma.