PTGS2 and cancer: In order to screen for active compunds with both anti-cancer and anti-inflammatory potential from W. ugandensis and further explain its diversified traditional use, an integrative strategy combining enzyme affinity ultrafiltration with corresponding multiple drug targets, i.e., COX-2, 5-LOX, Top I, and Top II was developed and coupled with high-performance liquid chromatography-mass spectrometry (AUF-HPLC-MS/MS) for the rapid screening and identification of natural compounds from W. ugandensis with both anti-inflammatory and anti-proliferative activities.