Wang [31] et al. demonstrated that MM-derived exosomes directly stimulate the growth, proliferation and invasion of endothelial cells by modulating multiple pathways, including signal transducer and activator of transcription 3 (STAT3), c-Jun N-terminal kinase (JNK), protein kinase B (Akt), p38 and p53-mediated pathways. The gene discussed is AKT1; the disease is Miyoshi myopathy.