IDH1 and diffuse astrocytoma: Broen et al. further confirmed this specificity of the T2-FLAIR mismatch for diffuse and anaplastic astrocytomas by completing a retrospective study of diffuse astrocytoma (IDH-mutant), diffuse oligodendroglioma (IDH-mutant 1p/19q co-deleted), anaplastic astrocytoma (IDH-mutant), anaplastic oligodendroglioma (IDH-mutant 1p/19q co-deleted) and IDH-WT (Glioblastoma-like) T2-FLAIR images [43].