The finding that SNAIL and SLUG are better prognostic markers of tumor progression compared to TWIST1 is also consistent with the results of Wallesch et al. [15] It is known that higher grades of astrocytic tumors (especially glioblastomas) are associated with a stronger expression of the TWIST1 protein, which is an independent predictor of poorer treatment outcomes [61]. This evidence concerns the gene SNAI2 and astrocytic tumor.