TNFRSF11B and periodontal disorder: As with the polycan, β-glucan derived from Saccharomyces cerevisiae reduced alveolar bone loss in diabetic rat models with periodontal disease via the downregulation of RANKL and upregulation of osteoprotegerin (OPG) [79,80] The Wistar rats that were administered soluble β-1,3/1,6-glucan from S. cerevisiae showed the suppression of periodontal bone loss induced by tooth ligature.