After activation, they change their phenotype similarly to tumor cells, losing contact inhibition and anchorage dependence, proliferating, gaining migratory activity and expressing large quantities of cytokines, chemokines, RANKL (receptor activator of nuclear factor kappa-β ligand), adhesion molecules, MMPs, and TIMPs (tissue inhibitor of metalloproteinase). This evidence concerns the gene TNFSF11 and neoplasm.