In murine models of RA, mice with knockdown of IL-18Rα (IL-18 receptor α) presented decreased levels of IL-6, IL-18, TNF-α, IFN-γ, and MMP3, as well as less severe disease progression [83], which can implicate the importance of this cytokine in the course of this affliction. The gene discussed is IL18; the disease is rheumatoid arthritis.