Specifically, SMAD1, ARNTL, WT1, RELB, SPIB and TCF7L2 had lower activity in SLE while GATA4, NFATC1, E2F2, PPARD, IRF3, STAT2, IRF1, STAT1 were identified as TFs with greater activity. Here, RELB is linked to systemic lupus erythematosus.