Specifically, SMAD1, ARNTL, WT1, RELB, SPIB and TCF7L2 had lower activity in SLE while GATA4, NFATC1, E2F2, PPARD, IRF3, STAT2, IRF1, STAT1 were identified as TFs with greater activity. This evidence concerns the gene GATA4 and systemic lupus erythematosus.