A different study using CRISPR/Cas9 parallelly identified that SCLC cells with loss of RB1 tumor suppressor gene are hyper-dependent on AURKB for their survival and inhibition with AURKB inhibitors significantly reduced cell proliferation demonstrating that loss of RB1 is synthetic lethal with AURKB inhibition [167]. Here, RB1 is linked to small cell lung carcinoma.