Furthermore, it was shown in asthma that airway epithelial cells secrete the lipid phosphatase inositol polyphosphate 4-phosphatase type I A (INPP4A) in the form of extracellular vesicles, which negatively regulate the phosphatidylinositol 3-kinase/serine/threonine protein kinase B (PI3K/Akt) pathway and inhibit airway inflammation and remodeling. Here, INPP4A is linked to asthma.