Siltuximab use is not recommended in COVID-19 patients with HIV, human herpes virus, Epstein–Barr virus, tuberculosis, neutrophils ≤ 1.0 × 109/L, platelets ≤ 50 × 109/L, AST/ALT values more than 5 times of its normal upper limit, and total bilirubin ≥ 2.0 times its normal upper limit [21]. This evidence concerns the gene GPT and tuberculosis.