This drug is not recommended as a COVID-19 treatment option in the cases of (i) aspartate transaminase/alanine aminotransferase (AST/ALT) values greater than 5 [13] or 10 [21] times of its normal upper limit, (ii) neutrophils < 500 cells/mmc, (ii) platelets < 50,000 cells/mmc, (iv) recognized sepsis by pathogens other than SARS-CoV-2, (v) presence of comorbidity that can lead to a poor prognosis, (vi) multiple organ failure, (vii) complicated diverticulitis or intestinal perforation, or (vii) ongoing skin infection [11,12,13,16,29]. This evidence concerns the gene GPT and skin infection.