Since the LRRK2 kinase activity is elevated in PD linked to LRRK2 mutations and common genetic variants are involved in the idiopathic form of PD (Di Maio et al., 2018), it would be good to find a way to modulate LRRK2 kinase activity to normal optimal physiological levels rather than inhibiting it completely, since LRRK2 might be involved in other important functions within cells. Here, LRRK2 is linked to Parkinson disease.