All these functions have been linked with impairment in autophagy and neuroinflammation in PD (Tait and Green, 2010, Waak et al., 2009) thus, making MAPT as a good potential target for LRRK2 pathway investigations and further connecting LRRK2 with PSP and AD. Here, LRRK2 is linked to supranuclear palsy, progressive, 1.