OXTR and intrahepatic cholestasis: Myometrium from women with intrahepatic cholestasis of pregnancy has greater oxytocin-mediated contractility than that from women without intrahepatic cholestasis of pregnancy,22 and, because cholic acid exposure increases the expression of oxytocin receptors in human myometrium,23 ursodeoxycholic acid-mediated alteration in the bile acid pool could reduce spontaneous preterm birth in women with intrahepatic cholestasis of pregnancy.12