Because TGF-β levels increase during acute pancreatitis (Riesle et al., 1997), and TGF-β induces trans-differentiation of exocrine pancreatic epithelial cells in culture (Handler et al., 2018; Liu et al., 2016), we investigated whether TGF-β cooperates with KRASG12D in duct-like and acinus-like organoids. This evidence concerns the gene TGFB1 and acute pancreatitis.