2017). Moreover, a similar mechanism has also been obtained in rheumatoid arthritis analysis (Wang et al. 2017). CT has also been identified as a dual inhibitor of p-STAT5 and p-STAT3 in chronic myeloid leukaemia (Dong et al. 2018). In the present study, our results indicate that the phosphorylation of STAT5 (at Tyr694) was significantly upregulated by CT in CD4+ T cells of the MCAO model. The gene discussed is STAT3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.