Specific protein pathways linked by IPA in this study include: (1) tauopathy (microtubule-associated protein tau [MAPT] and glial fibrillary acidic protein [GFAP]), (2) axon loss (MAPT) and (3) cerebral amyloid angiopathy (cystatin-C [CST3] and vimentin [VIM]). The gene discussed is CST3; the disease is cerebral amyloid angiopathy.