TG and major depressive disorder: Bommer et al. [16] observed that adults with "subclinical" or "remitted" hyperthyroidism (n = 45) had the following: (a) more behavioral abnormalities which included reduced well-being with feelings of fear (43% versus 10% for controls), hostility, inability to concentrate, fearful-agitated syndrome (dominated mainly early at onset of the disease) and depression (dominated mainly after longer periods of normalized thyroid hormone levels), and (b) marked impairment of neuropsychological functioning particularly in relapse after 2.5 yrs (more than 25% versus 2% for controls).