ANGPT2 and infection: First and third trimester infections led to reduced levels of angiopoietin-2 (ANG-2) and increased levels of soluble TEK receptor tyrosine kinase (sTIE-2), respectively (median [IQR], ANG-2 –Pv-1st tri 4.4 ng/mL [1.0–6.6] vs. NI 6.8 ng/mL [3.5–12.4], p = 0.03; sTIE-2 –Pv-3rd tri 18.5 ng/mL [11.7–24.7] vs. NI 13.9 ng/mL [9.1–19.0], p = 0.008).