Based on somatic mutations in DLBCL, germline mutations in C elegans, and experimental overexpression and RNAi knockdown experiments in human DLBCL cells, we hypothesised that germline loss of function Fbxo10 mutations in mice would cause increased BCL2 protein accumulation in mature B cells and GC B cells and corresponding increased B cell accumulation. The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.