FBXO10 is particularly highly expressed by GC B cells and appears to be most important for regulating BCL2 protein levels in GCB-type DLBCL, based on the reduced FBXO10 mRNA expression and low frequency heterozygous FBXO10 hypomorphic missense alleles in DLBCL and the high FBXO10 mRNA expression in GC B cells [26]. This evidence concerns the gene FBXO10 and diffuse large B-cell lymphoma.