The B-cell leukemia-lymphoma-2 (BCL2) gene was discovered because hybrid BCL2-Immunoglobulin Heavy chain (IGH) fusion transcripts [6–8] resulting in aberrantly high BCL2 protein expression [9] are often created by a t(14; 18) chromosomal translocation that occurs in 85% of human follicular B cell lymphomas [10,11] and 34% of germinal centre (GC)-type diffuse large B-cell lymphomas (DLBCL) [12]. Here, BCL2 is linked to diffuse large B-cell lymphoma.