The unexpected finding that E-cadherin is internalized by Rac1 activation without significant dissociation of catenins in primary keratinocytes (Figs. 1, 2, and 3) is consistent with data from tumor cell lines that the disruption of cell–cell adhesion may not use the classical internalization routes (Akhtar and Hotchin, 2001). Here, CDH1 is linked to neoplasm.