CDH17 and neoplasm: Destabilization of cadherin-dependent junctions by PAK1 activation is consistent with the role of other PAK family members in the adhesion of tumor cell lines (Fram et al., 2014; Ismail et al., 2017; Morse et al., 2016; Selamat et al., 2015) and the well-established PAK1 function in promoting tumor migration and metastasis (Kumar and Li, 2016).