CDH17 and head and neck neoplasm: Second, in normal keratinocytes, E-cadherin–containing vesicles appear to be micropinosomes (around 100-nm vesicles; Fig. 10 A; Egami et al., 2014) compared with macropinosomes (large vacuoles 0.2–5 μm; Ha et al., 2016) during cadherin uptake in transformed cell lines (head and neck tumor cell lines; Akhtar and Hotchin, 2001; Akhtar et al., 2000).