ARHGDIA and cancer: For instance, the interactionof RhoGDI-1 with EphrinB1 has been shown to stimulate RhoA displacementfrom the RhoA–RhoGDI-1 complex leading to RhoA activation,which promoted breast cancer cell migration.36 Furthermore, the RhoGDI-1 interaction with 14–3–3τhas also been shown to support cell migration and invasion in breastcancer by disturbing RhoGDI-1 association with its targets, RhoA,Rac1 and Cdc42.37 These data suggest thatmore detailed knowledge of the RhoGDI function and target proteinscould help in the search for new therapeutic avenues in cancer.