For instance, the interactionof RhoGDI-1 with EphrinB1 has been shown to stimulate RhoA displacementfrom the RhoA–RhoGDI-1 complex leading to RhoA activation,which promoted breast cancer cell migration.36 Furthermore, the RhoGDI-1 interaction with 14–3–3τhas also been shown to support cell migration and invasion in breastcancer by disturbing RhoGDI-1 association with its targets, RhoA,Rac1 and Cdc42.37 These data suggest thatmore detailed knowledge of the RhoGDI function and target proteinscould help in the search for new therapeutic avenues in cancer. This evidence concerns the gene RHOA and breast carcinoma.