Inflammatory macrophages mainly release IL‐6, which is responsible for the SARS‐CoV‐2 related macrophage activation syndrome, however, the presence of this cytokine produces the decrease of NK and CD8+ T cells,28, 47 a condition found in patients with severe SARS‐CoV‐2 infections.28, 48, 49 This scenario produces in the SARS‐CoV‐2 patient a state of constant hyper‐inflammation, without macrophage immune regulation. This evidence concerns the gene CD8A and macrophage activation syndrome.