To better understand the role of LRP10 expression in the diseased brain, we analysed LRP10 protein expression in brain specimens from five patients carrying heterozygous variants in the LRP10 gene (p.Arg151Cys, p.Ala212Ser fs*17, p.Arg235Cys, p.Gly453Ser, p.Asn517del) with varying phenotypes from a typical late-onset PD to PD with dementia, or DLB. This evidence concerns the gene LRP10 and dementia.