Although no apparent differences in size and staining intensity in LRP10-positive vesicles were observed between LRP10-expressing cells from NDC, PD and the majority of LRP10 variant carriers, we observed significantly larger and clustered LRP10-positive vesicles in the brainstem tissue from the LRP10 p.Arg235Cys variant carrier (patient III, Fig. 4c; NDC I/II/III/IV vs. p.Arg235Cys, p < 0.001; PD I/II/III vs. p.Arg235Cys, p < 0.001; p.Arg151Cys/p.Ala212Ser fs*17/p.Gly453Ser/p.Asn517del vs. p.Arg235Cys, p < 0.001). The gene discussed is LRP10; the disease is Parkinson disease.