LRP10 and supranuclear palsy, progressive, 1: Moreover, the association of LRP10 variants with progressive supranuclear palsy (PSP) [87] and amyotrophic lateral sclerosis (ALS) [63], together with the data showing that LRP10 is a driver of a specific molecular subtype of Alzheimer’s disease (AD) [62], provide evidence of potential mechanistic roles for LRP10 across a broader spectrum of neurodegenerative diseases.