LOX and rheumatoid arthritis: According to Sano et al. [20], most 20:4n-6-, 20:5n-3-, and 22:6n-3-derived metabolites from the COX, 5-LOX, 12/15-LOX, and cytochrome P450 pathways were elevated in RA SF compared to OA SF, and severe RA and severe OA could be differentiated by biomarkers, such as 5-HETE, 12-HETE, LXA4, protectin D1 (PD1), 12-HEPE, and 17-HDHA.