TBC1D4 and type 2 diabetes mellitus: We found indication of an interaction effect, suggesting an attenuation in the association between the TBC1D4 p.Arg684Ter risk variant and odds of type 2 diabetes per kJ kg−1 day−1 unit increase in daily physical activity (OR 0.99 [95% CI 0.97, 1.00], p = 0.11)].