In melanoma cell lines, mitoSPIRE binds directly to MYO5A, which recruits this motor to mitochondrial fission sites adjacent to DRP1 puncta; MYO5A recruitment facilitates mitochondrial fission, whereas MYO5A depletion leads to mitochondrial elongation (Araujo et al., 2019 preprint). Here, MYO5A is linked to melanoma.