Transfection of these reporters into ZNF598 KO, uS10-KI or eS10-KI cells in the absence of viral infection resulted in a similar poly(A)-dependent repression of firefly luciferase protein levels, indicating that a loss of RQC activity does not allow for enhanced protein production for mRNAs containing a 5′ UTR poly(A) sequence (Fig. 4F). This evidence concerns the gene RPS20 and viral infectious disease.