ZNF598 and infection: Because only a single time point showed a statistically significant difference in the ZNF598 KO cells due to variance observed by comparing ratios of ratios, we modified the labeling scheme for this series of experiments such that heavy-labeled uS10-KI cells and light-labeled parental cells were both infected at an MOI of 5 and the two cellular genotypes were collected over a timecourse post infection and mixed (Fig. 3A).