While a potential disruption in the S-MAG/L-MAG ratio has yet to be specified in MS, a study using the EAE mouse model observed a depletion in MAG protein levels in the spinal cord, resulting in an increase in PARP-1 cleavage, and an increase in apoptosis activation in glial and neuronal cells (Skundric et al., 2008). This evidence concerns the gene MAG and myeloid sarcoma.