IL6R and asthma: Higher genetically-instrumented sIL-6R levels were associated with a modestly but significantly increased risk of overall asthma (OR per one standard deviation increment in inverse-rank normalized sIL-6R level, 1.02; 95%CI, 1.01–1.03; P = 0.004; Figure 1) with the use of inverse-variance weighted meta-analysis method.