We found that soluble IgG2, after LN-NET addition, were significantly increased in SLE naïve B cells supernatants; conversely, this increment was not observed for IgG1 and IgG3 (Figure 2A), as well as IgM and IgA levels (Figure 2B), neither in SLE, nor in normal B cells. Here, CD40LG is linked to systemic lupus erythematosus.