According to the Somatic Mutation Catalog of Cancer (COSMIC), the frequency of ATM gene mutation is 0.7% in 713 ovarian cancers, 0.9% in central nervous system cancers, 1.9% in 1,120 breast cancers, 2.1% in 847 kidney cancers, 18% in 74 colon cancer, 7.2% in 1,040 lung cancers, and 11.1% in 1,790 hematopoietic and lymphoid tissue cancers. The gene discussed is ATM; the disease is cancer.