SH-group targeting and induction of massive apoptosis (STIMA-1), a low molecular weight compound with some structural similarity to CP-31398, known as a p53 inhibitor, stimulates the binding of mutant p53 to DNA in vitro, induces the expression of the p53 target protein, and can cause cell death in tumor cells expressing the mutant p53 (Zache et al., 2008). Here, TP53 is linked to neoplasm.