ACE and hypertensive disorder: Shortly, HMGB1 is (1) related to an increased risk of thrombosis; (2) HMGB1 gene polymorphisms are associated with hypertension; (3) HMGB1 regulates ACE II receptors which act as a counterbalance to the Angiotensin-converting enzyme (ACE), the central component of the renin-angiotensin system (Chen et al., 2020b) essential for SARS-CoV-2 infection (Chen et al., 2020b; Street, 2020; Figure 1B).