Previous studies have shown that the expression of AREG in granulosa cells is positively correlated to the oocyte retrieval rate, oocyte maturation rate, fertilization rate, and good-quality embryo rate (Huang et al., 2015), and adding AREG during IVM significantly increases the oocyte maturation rate and embryo development potential in PCOS patients (Sanchez et al., 2017). This evidence concerns the gene AREG and polycystic ovary syndrome.