Moreover, CAFs transfer exosomal miR-92a-3p to CRC cells and facilitate cell stemness, EMT, metastasis, and 5-FU/L-OHP resistance by directly targeting FBXW7 and MOAP1 (Hu et al., 2019); it also increases sphere formation and the levels of stemness markers CD133, CD44, and OCT4; enhances the expression of N-cadherin and vimentin; and suppresses mitochondrial apoptosis in CRC. This evidence concerns the gene CD44 and colorectal carcinoma.