RHOA and familial pancreatic carcinoma: In addition, circ-IRAS can also access HUVEC through exosomes derived from pancreatic cancer cells, significantly decreasing the levels of miR-122 and ZO-1; increasing the levels of RhoA, RhoA-GTP, and focal adhesions; and subsequently increasing the permeability of the endothelial monolayer and facilitating tumor invasion and metastasis (Li J. et al., 2018).