Moreover, glioma A172 cells can also induce angiogenesis by secreting exosomes containing linc-POU3F3 and upregulate the expression level of angiogenesis-related genes such as bFGF, bFGFR, and VEGFA in human brain microvascular endothelial cells (HBMECs) (Lang et al., 2017a). Here, VEGFA is linked to central nervous system cancer.