The expression of S100A16 was down-regulated in ACC (Adrenocortical carcinoma), ESCA (Esophageal carcinoma), KICH (Kidney Chromophobe), PRAD (Prostate adenocarcinoma), SKCM (Skin Cutaneous Melanoma), and TGCT (Testicular Germ Cell Tumors) (Figure 6A). The gene discussed is S100A16; the disease is prostate adenocarcinoma.