Screening GEPIA database information showed that S100A16 expression was up-regulated in BLCA (Bladder Urothelial Carcinoma), CESC (Cervical squamous cell carcinoma and endocervical adenocarcinoma), COAD (Colon adenocarcinoma), DLBC (Lymphoma Diffuse Large B Somatic Lymphoma), GBM (Glioblastoma multiforme), LGG (Brain Lower Grade Glioma), LUSC (Lung squamous cell carcinoma), OV (Ovarian serous cystadenocarcinoma), PAAD (pancreatic tumor), READ (Rectum adenocarcinoma), STAD (rectal cancer), THYM (thymoma). The gene discussed is S100A16; the disease is central nervous system cancer.