CASP1 and acute kidney injury: The nlrp3 or caspase-1 knockout iohexol-induced AKI mice and iohexol-treated HK-2 cells with MCC950 pretreatment exhibited upregulated levels of HIF-1α (hypoxia inducible factor 1, alpha subunit), BNIP3, and LC3B-II, as well as enhanced colocalization of LC3B with BNIP3 and mitochondria (Lin Q. et al., 2020).