Wei et al. (2010) found that PHF10 inhibited the expression of caspase-3 and damaged the programmed cell death pathway in human GC. By targeting PHF10 in GC, microRNA-409-3p was also verified to suppress cell proliferation and apoptosis (Li et al., 2012). Furthermore, the predictive power of PHF10 was tested in another independent data set, GSE38749. As shown in Figure 4D, patients with a higher expression of PHF10 exhibited a lower survival rate than patients with lower expression, showing its risk roles. This evidence concerns the gene CASP3 and gastric cancer.