As VEGF, the main mediator of sprouting angiogenesis, promotes not only angiogenesis, but also immunosuppression (Motz and Coukos, 2011), there might be an indication that the desmoplastic angiogenic HGP is related to an immunosuppressive TME, which is supported by the presence of tumor surrounding immune cells that are not penetrating the tumor (van Dam et al., 2018). Here, VEGFA is linked to neoplasm.