Notably, in human hepatocellular carcinoma cells, resveratrol suppressed invasion of cells through inhibition of tumor necrosis factor-α-mediated matrix metalloproteinase 9 (MMP9) expression (Yu et al., 2008) and caused cell cycle arrest via the activation of the p53-dependent pathway in colorectal cancer (Liu et al., 2019). This evidence concerns the gene MMP9 and colorectal cancer.