Some tRFs are known to directly bind mRNA target in manner similar to canonical miRNAs, such as APOER2 as an endogenous target of tRF5-GluCTC in respiratory tract infection caused by respiratory syncytial virus (35), the generation of tRF-CU1276 is dependent on Dicer1, which can be associated with Argonaut proteins and inhibit proliferation and modulates the molecular response to DNA damage by silencing expression of its target gene PRA1 in B cell lymphoma (36). This evidence concerns the gene DICER1 and Respiratory tract infection.