Even though, we found that reduction of THBS1 expression partially reversed the inhibition effect of tRF-17-79MP9PP on TGF-β1 protein expression in cells in the present study, as well as in the previous study showing the addition of THBS1 antibody, αvβ3 and CD47 reduced TGF-β1 activation in the MCF-7 breast cancer cells treated with tamoxifen (46). Here, THBS1 is linked to breast cancer.