Some miRNAs, such as miRNA-148, miR-124, miR-320 and miR-141, have been shown to negatively regulate the expression of NRP-1 in hepatocellular carcinoma (HCC) (21), glioma (22), cholangiocarcinoma (23) and pancreatic ductal carcinoma (7), respectively, supporting the theory that one target gene can be regulated by multiple miRNAs (17). Here, NRP1 is linked to central nervous system cancer.