GH1 and pituitary gland adenoma: Acromegaly, mostly caused by growth hormone-secreting pituitary adenoma, is an endocrine and metabolic disease characterized by excessive secretion of growth hormone (GH) and concomitant increases in insulin-like-growth factor 1 (IGF-1) levels, leading to progressive somatic disfigurement and organ overgrowth (1, 2).