TPX2 and melanoma: Kaplan-Meier analysis showed (Figure 8) that 5 of the top 10 Hub genes (FOXM1, EXO1, KIF20A, TPX2, CDC20) were significantly correlated with prognosis (p<0.01), and that the relationship between all five hub genes and the prognosis of melanoma patients was such that high expression of the gene was accompanied by low patient Prognosis.