TGFB1 and lung adenocarcinoma: TGFBI (transforming growth factor β-induced protein), encoded by TGFBI gene, was first identified in a human lung adenocarcinoma cell line A549 treated with TGFB (transforming growth factor β), it contains an RGD (Arg-Gly-Asp) motif that can serve as a ligand recognition site for integrins (25).