In dedifferentiated chondrosarcoma, HLA-A heavy chain expression was scored positive in 85% (17 out of 20 tumors analyzed) and heterogeneous in 15% (3 out of 20 tumors analyzed) of the tumors, HLA-B, -C heavy chain expression was scored positive in 100% of the tumors (20 out of 20 tumors analyzed). Here, HLA-B is linked to chondrosarcoma.