Subsequently, the risk score of each patient with HNSCC from the TCGA database was calculated as follows: risk score = (−0.029572) *expression of DNMT1 + (−0.038603) *expression of DNMT3A + (0.021496) *expression of NSUN5 (Figure 4C). Here, NSUN5 is linked to head and neck squamous cell carcinoma.