In previous studies, deep learning of radiomics has shown unique value in diagnosis and prognosis in the assessment of liver fibrosis in chronic hepatitis B (24), access to tumor-infiltrating CD8 cells, and responses to anti-PD-1 or anti-PD-L1 immunotherapy (25) that could predict lymph node metastasis in ESCC and colorectal cancer (26, 27). The gene discussed is CD274; the disease is esophageal squamous cell carcinoma.