Previous studies have mostly used parametric prediction models constructed with clinical baseline characteristics (such as tumor size, cirrhosis, tumor number, and microvascular infiltration) and single-molecule biomarkers (such as alpha-fetoprotein [AFP] and Des-γ carboxyl-Carboxyl of enzyme) to predict the prognosis of HCC (AlSalloom, 2016). The gene discussed is DES; the disease is neoplasm.