To evaluate whether the TCR repertoire of activated CD8+ T cells was remodeled following CBZ culture, we analyzed in vitro expanded HLA-B*15:02-positive PBMCs from two drug-naïve donors (AP022, AP026), five CBZ-induced SJS cases (T00016, T00024, E10076, E10314, E10630) and one CBZ-induced TEN case (E10056) (Table 1). Here, CD8A is linked to toxic epidermal necrolysis.