CD19 and Hepatitis: Further stratified analysis of the frequency of Breg subsets in patients according to HBV replication and liver inflammation degree showed that patients with active liver inflammation (ALT ≥ 2*ULN) and virus replication (HBeAg positive) had higher frequency of Breg subsets, and in these patients, the Breg subset was dominated by CD19+CD24hiCD38hi (Figures 3B, C).